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BOR - Papers in Press, published online ahead of print July 30, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.030932
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Submitted April 14, 2004
Returned for revision May 13, 2004
Accepted July 7, 2004

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Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures

Emanuela Maioli *, Vittoria Fortino , and Adriana Pacini

* To whom correspondence should be addressed. E-mail: maioli{at}unisi.it.

Abstract
Preeclampsia is a disorder associated with pregnancy that affects both the mother and the fetus. Typical features of the disease are maternal hypertension, proteinuria and edema, and fetal growth retardation. Although the etiological details are still being debated, there is consensus that the starting point is deficient placentation in the first half of pregnancy. The crucial early steps are reduced trophoblast invasiveness and enhanced apoptotic death. In this review, we demonstrate that PTHrP is involved not only in the maternal and fetal failures, but also in the etiological aspects of the disease. We hypothesize that reduced local production of the peptide is a major causative event.

Key words: Pregnancy • Apoptosis • Cytokines • Placenta • Trophoblast


This article has been cited by other articles:


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F. Meziani, A. Tesse, S. Welsch, H. Kremer, M. Barthelmebs, R. Andriantsitohaina, F. Schneider, and A. Gairard
Expression and Biological Activity of Parathyroid Hormone-Related Peptide in Pregnant Rat Uterine Artery: Any Role for 8-Iso-Prostaglandin F2{alpha}?
Endocrinology, February 1, 2008; 149(2): 626 - 633.
[Abstract] [Full Text] [PDF]


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