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BOR - Papers in Press, published online ahead of print October 20, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.033837
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Submitted June 29, 2004
Returned for revision July 15, 2004
Accepted October 5, 2004

Pregnancy


Inhibition of the Beta-Catenin Signaling Pathway in Blastocyst and Uterus During the Window of Implantation in Mice

Jing Li , Jian V. Zhang , Yu-Jing Cao , Jia-Xi Zhou , Wei-Min Liu , Xiu-Jun Fan , and En-Kui Duan *

* To whom correspondence should be addressed. E-mail: duane{at}ioz.ac.cn.

Abstract
Beta-cateninthe mammalian homolog of Drosophila armadillo protein, was first identified as a cadherin-associated protein at cell-cell junctions. Another function of beta-catenin is the transduction of cytosolic signals to the nucleus in a variety of cellular contexts, which are usually elicited by the active form of beta-catenin. The aim of this study was to examine the potential role of active beta-catenin in the mouse embryo and uterus during embryo implantation. As shown by these results, active beta-catenin was detected differentially in mouse embryos and uteri during the periimplantation period. Aberrant activation of beta-catenin by LiCl, a well-known GSK3 (glycogen synthase kinase3) inhibitor, significantly inhibited blastocyst hatching and subsequent adhesion and outgrowth on FN (fibronectin). Results obtained from pseudopregnant and implantation-delayed mice imply an important role for implanting blastocysts on the temporal and spatial changes of active beta-catenin in the uterus during the window of implantation. Collectively, these results suggest that the beta-catenin signaling pathway is inhibited in both blastocyst and uterus during the window of implantation, which may represent a new mechanism to synchronize the development of preimplantation embryos and differentiation of the uterus during this process.

Key words: Embryo • Pregnancy • Implantation • Signal transduction • Steroid hormones


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