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Abstract
Selenoprotein P (SEPP1), an extracellular glycoprotein of
unknown function, is a unique member of the selenoprotein
family that, depending on species, contains 10-17
selenocysteines in its primary structure; in contrast all
other family members contain a single selenocysteine
residue. Selenoprotein P-null (Sepp1-/-)
male, but not female, mice are infertile but the cellular
basis of this male phenotype has not been defined. In
this study we demonstrate that mature spermatozoa of
Sepp1-/- males display a specific set of
flagellar structural defects that develop temporally
during spermiogenesis and post-testicular maturation in
the epididymis. The flagellar defects include a
development of a truncated mitochondrial sheath, an
extrusion of a specific set of axonemal microtubules and
outer dense fibers from the principal piece, and,
ultimately a hairpin-like bend formation at the
midpiece-principal piece junction. The sperm defects
found in Sepp1-/- males appear be the
same as those observed in wild type
(Sepp1+/+) males fed a low selenium diet.
Supplementation of dietary selenium levels for
Sepp1-/-males neither reverses the
development of sperm defects nor restores fertility.
These data demonstrate that selenoprotein P is required
for development of functional spermatozoa and indicate
that it is an essential component of the selenium delivery
pathway for developing germ cells.
Key words:
Gamete Biology •
Epididymis •
Sperm •
Sperm maturation •
Spermatid
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