Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print January 18, 2006.
Biol Reprod 2006, 10.1095/biolreprod.105.045997
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
74/5/772    most recent
biolreprod.105.045997v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stepan, H.
Right arrow Articles by Walther, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stepan, H.
Right arrow Articles by Walther, T.
Agricola
Right arrow Articles by Stepan, H.
Right arrow Articles by Walther, T.
Submitted July 30, 2005
Returned for revision August 23, 2005
Accepted January 17, 2006

Minireview


New Insights into the Biology of Preeclampsia

Holger Stepan *, Renaldo Faber , Nadja Dornhöfer , Berthold Huppertz , Andrea Robitzki , and Thomas Walther

* To whom correspondence should be addressed. E-mail: holger.stepan{at}medizin.uni-leipzig.de.

Abstract
Despite recent research progress, the biology of preeclampsia is still poorly understood and effective prediction or causal therapy have not yet emerged. Nevertheless, recent studies have documented new and exciting pathophysiological mechanisms for the origin and development of preeclampsia. They provide a more differentiated view on alterations of particular peptide systems with strong impact on angiogenesis and cardiovascular regulation in this pregnancy disorder. With the identification of the anti-angiogenic factor soluble FLT1 (soluble fms-like tyrosine kinase 1) and the agonistic autoantibody to the angiotensin II type 1 receptor (AGTR1-AA), two factors have been described with a clear linkage to the development of the disease. This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia.

Key words: Pregnancy • Placenta • Signal transduction • Trophoblast


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Collino, B. Bussolati, E. Gerbaudo, L. Marozio, S. Pelissetto, C. Benedetto, and G. Camussi
Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells
Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1185 - F1194.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. P. Thomas, J. I. Andrews, and K. Z. Liu
Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta
FASEB J, December 1, 2007; 21(14): 3885 - 3895.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
A.-K. Wikstrom, A. Larsson, U. J. Eriksson, P. Nash, S. Norden-Lindeberg, and M. Olovsson
Placental Growth Factor and Soluble FMS-Like Tyrosine Kinase-1 in Early-Onset and Late-Onset Preeclampsia
Obstet. Gynecol., June 1, 2007; 109(6): 1368 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y.-L. Dong, D. M. Reddy, K. E. Green, M. S. Chauhan, H.-Q. Wang, M. Nagamani, G. D.V. Hankins, and C. Yallampalli
Calcitonin Gene-Related Peptide (CALCA) Is a Proangiogenic Growth Factor in the Human Placental Development
Biol Reprod, May 1, 2007; 76(5): 892 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. C. Zhou, S. Ahmad, T. Mi, L. Xia, S. Abbasi, P. W. Hewett, C. Sun, A. Ahmed, R. E. Kellems, and Y. Xia
Angiotensin II Induces Soluble fms-Like Tyrosine Kinase-1 Release via Calcineurin Signaling Pathway in Pregnancy
Circ. Res., January 5, 2007; 100(1): 88 - 95.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by the Society for the Study of Reproduction.