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Abstract
Germ cells constitute a highly specialized cell population
that is indispensable for the continuation and evolution
of the species. Recently, several research groups have
shown that these unique cells can be produced in vitro
from pluripotent stem cells. Furthermore, live births of
offspring using induced germ cells have been reported in
one study. These results suggest that it may be possible
to investigate germ cell development ex vivo and to
establish novel reproductive technologies. To this end, it
is critical to assess if gamete induction processes in
vitro faithfully recapitulate normal germ cell development
in vivo. Here, this issue is discussed with a focus on the
germ line specification and the sex-specific development
of pre- and postnatal germ cells. The aim of this paper is
to concisely summarize the past progress and to present
some future issues for the investigation into in vitro
gamete production from pluripotent stem cells.
Key words:
Assisted Reproductive Technology •
Developmental biology •
Gametogenesis
This article has been cited by other articles:
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  C. E. Gargett Review Article: Stem Cells in Human Reproduction Reproductive Sciences, July 1, 2007; 14(5): 405 - 424. [Abstract] [PDF]
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