Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print March 7, 2007.
Biol Reprod 2007, 10.1095/biolreprod.107.060186
This Article
Right arrow Full Text (Rapid PDF)
Right arrow [Supplemental Movies]
Right arrow All Versions of this Article:
77/1/37    most recent
biolreprod.107.060186v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jin, J.
Right arrow Articles by Yan, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jin, J.
Right arrow Articles by Yan, W.
Agricola
Right arrow Articles by Jin, J.
Right arrow Articles by Yan, W.
Submitted January 18, 2007
Returned for revision February 21, 2007
Accepted March 6, 2007

Gamete Biology


Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility

Jingling Jin , Nange Jin , Huili Zheng , Seungil Ro , Dora Tafolla , Kenton M. Sanders , and Wei Yan *

* To whom correspondence should be addressed. E-mail: wyan{at}unr.edu.

Abstract
Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 and Catsper2 which have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice. Here we report that Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions. Our data demonstrate that both CATSPER3 and CATSPER4 are required for hyperactivated sperm motility during capacitation and for male fertility. The present study also demands a revisit on the idiopathic male infertility patients who show normal sperm counts and normal initial motility for defects in sperm hyperactivated motility and for potential CATSPER gene mutations. The CATSPER channel may also be an excellent drug target for male contraceptives.

Key words: Sperm • Sperm capacitation • Sperm maturation • Sperm motility and transport


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
S. S. Suarez
Control of hyperactivation in sperm
Hum. Reprod. Update, November 1, 2008; 14(6): 647 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. A. Sutton, M. K. Jungnickel, and H. M. Florman
A polycystin-1 controls postcopulatory reproductive selection in mice
PNAS, June 24, 2008; 105(25): 8661 - 8666.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
V. Torres-Flores, N. L. Garcia-Sanchez, and M. T. Gonzalez-Martinez
Intracellular Sodium Increase Induced by External Calcium Removal in Human Sperm
J Androl, January 1, 2008; 29(1): 63 - 69.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
S. Ro, C. Park, R. Song, D. Nguyen, J. Jin, K. M. Sanders, J. R. McCarrey, and W. Yan
Cloning and expression profiling of testis-expressed piRNA-like RNAs
RNA, October 1, 2007; 13(10): 1693 - 1702.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2007 by the Society for the Study of Reproduction.