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BOR - Papers in Press, published online ahead of print June 20, 2007.
Biol Reprod 2007, 10.1095/biolreprod.107.062703
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Submitted May 9, 2007
Returned for revision June 5, 2007
Accepted June 18, 2007

Gamete Biology


Changes in Histone Acetylation During Postovulatory Aging of Mouse Oocyte

Jun-Cheng Huang , Li-Ying Yan , Zi-Li Lei , Yi-Liang Miao , Li-Hong Shi , Ji-Wen Yang , Qiang Wang , Ying-Chun Ouyang , Qing-Yuan Sun , and Da-Yuan Chen *

* To whom correspondence should be addressed. E-mail: chendy{at}ioz.ac.cn.

Abstract
Since some animals and human beings potentially engage in sexual activity at any day of the menstrual cycle, this may cause fertilization of postovulatory aged oocytes, which result in decreased potential of embryo development and longevity of offspring. To investigate the involvement of histone acetylation in the function of postovulatory aging, we examined the changes of histone acetylation by immunostaining with specific antibodies against various acetylated lysines on histone H3 and H4. We found that the acetylation levels of lysine 14 on histone H3 and lysines 8, 12 on histone H4 in mouse oocytes were gradually increased during in vivo and in vitro postovulatory aging. Furthermore, the acetylation levels on these sites were markedly decreased or increased when the process of postovulatory aging was artificially delayed or accelerated, respectively. These results indicated that the gradual acetylation on some lysines of histone H3 and H4 was one of the phenomena in the process of postovulatory aging. Moreover, raising the level of histone acetylation by trichostatin A can accelerate the progression of postovulatory aging, suggesting that alteration of the acetylation on the histone H3 and H4 could affect the progression of postovulatory aging in mouse oocytes.

Key words: Gamete Biology • Aging • Oocyte development • histone acetylation


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K. T. Jones
Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age
Hum. Reprod. Update, March 1, 2008; 14(2): 143 - 158.
[Abstract] [Full Text] [PDF]


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