Highlights:

Mary Ann Handel, John Eppig, and Mitch Eddy

Highlights
Biol Reprod 2005 73: 849. [Full Text] [PDF]  

Embryo:

S.J. Adamiak, K. Mackie, R.G. Watt, R. Webb, and K.D. Sinclair

Impact of Nutrition on Oocyte Quality: Cumulative Effects of Body Composition and Diet Leading to Hyperinsulinemia in Cattle
Biol Reprod 2005 73: 918-926. [Abstract] [Full Text] [PDF]  

Summary: The cumulative effects of diet on oocyte quality in cattle are dependant on body composition

Gamete Biology:

Véronique Thimon, Sonia Métayer, Maya Belghazi, Françoise Dacheux, Jean-Louis Dacheux, and Jean-Luc Gatti

Shedding of the Germinal Angiotensin I-Converting Enzyme (gACE) Involves a Serine Protease and Is Activated by Epididymal Fluid
Biol Reprod 2005 73: 881-890. [Abstract] [Full Text] [PDF]  

Summary: We have addressed the mechanisms by which the germinal isoform of the angiotensin I-converting enzyme is released in vivo during the sperm transit in the epididymal duct

Yuki Morito, Yukihiro Terada, Soichi Nakamura, Junko Morita, Tomoko Yoshimoto, Takashi Murakami, Nobuo Yaegashi, and Kunihiro Okamura

Dynamics of Microtubules and Positioning of Female Pronucleus During Bovine Parthenogenesis
Biol Reprod 2005 73: 935-941. [Abstract] [Full Text] [PDF]  

Summary: In bovine parthenogenesis, the maternal centrosome, which mainly consists of gamma-tubulin, may play a role as a functional centrosome and organize cytoplasmic microtubules to move the female pronucleus into the cell center

Margaret C. Pace and Peter Thomas

Steroid-Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3-Kinase/Akt Signal Transduction Pathway
Biol Reprod 2005 73: 988-996. [Abstract] [Full Text] [PDF]  

Summary: Activation of cAMP-independent signal transduction pathways, including the PI3K/Akt pathway, is necessary for steroid-induced GVBD in Atlantic croaker oocytes

Yanfeng Dai, Barbara Newman, and Robert Moor

Translational Regulation of MOS Messenger RNA in Pig Oocytes
Biol Reprod 2005 73: 997-1003. [Abstract] [Full Text] [PDF]  

Summary: Mos mRNA translation in porcine oocytes is subject to more complex controls than that in lower vertebrates

Yi-Liang Miao, Xin-Yong Liu, Tian-Wu Qiao, De-Qiang Miao, Ming-Jiu Luo, and Jing-He Tan

Cumulus Cells Accelerate Aging of Mouse Oocytes
Biol Reprod 2005 73: 1025-1031. [Abstract] [Full Text] [PDF]  

Summary: Cumulus cells accelerated the aging progression of both in vivo matured and in vitro matured mouse oocytes

Govindhaswamy Umapathy, Sadanand Sontakke, Anuradha Reddy, Shakeel Ahmed, and S. Shivaji

Semen Characteristics of the Captive Indian White-Backed Vulture (Gyps bengalensis)
Biol Reprod 2005 73: 1039-1045. [Abstract] [Full Text] [PDF]  

Summary: The collection and evaluation of semen from the Indian white-backed vulture, a critically endangered bird, is a critical first step in efforts to breed this species in captivity

C.H. Yeung, J.P. Barfield, and T.G. Cooper

Chloride Channels in Physiological Volume Regulation of Human Spermatozoa
Biol Reprod 2005 73: 1057-1063. [Abstract] [Full Text] [PDF]  

Summary: Human sperm volume regulation under physiological conditions can be inhibited by anion channel blockers, and involves the chloride channel family member Clcn3, which is expressed at the protein and mRNA levels and localized on the sperm tail

Male Reproductive Tract:

Ying Li, Crystal A. Putnam-Lawson, Heather Knapp-Hoch, Patrick J. Friel, Debra Mitchell, Randy Hively, and Michael D. Griswold

Immunolocalization and Regulation of Cystatin 12 in Mouse Testis and Epididymis
Biol Reprod 2005 73: 872-880. [Abstract] [Full Text] [PDF]  

Summary: CST12 protein is expressed in Sertoli cells in testis and Cst12 mRNA is upregulated by estradiol in epididymis

Christopher J. Thompson, Susan M. Ross, Janan Hensley, Kejun Liu, Susanna C. Heinze, S. Stanley Young, and Kevin W. Gaido

Differential Steroidogenic Gene Expression in the Fetal Adrenal Gland Versus the Testis and Rapid and Dynamic Response of the Fetal Testis to Di(n-butyl) Phthalate
Biol Reprod 2005 73: 908-917. [Abstract] [Full Text] [PDF]  

Summary: Di(n-butyl) phthalate produces rapid and transient alterations of gene expression in the fetal testis and inhibits steroidogenesis in both the fetal testis and adrenal gland through distinct mechanisms

Motoko Mukai, Qiang Dong, Matthew P. Hardy, Hiroaki Kiyokawa, Richard E. Peterson, and Paul S. Cooke

Altered Prostatic Epithelial Proliferation and Apoptosis, Prostatic Development, and Serum Testosterone in Mice Lacking Cyclin-Dependent Kinase Inhibitors
Biol Reprod 2005 73: 951-958. [Abstract] [Full Text] [PDF]  

Summary: Studies of knockout mice demonstrate different roles of the cell-cycle regulators CDKN1A and CDKN1B in prostatic epithelial proliferation, differentiation, and apoptosis

Kexiong Zhang, Rui Gao, Haoxing Zhang, Xin Cai, Chunhua Shen, Chaoqun Wu, Shouyuan Zhao, and Long Yu

Molecular Cloning and Characterization of Three Novel Lysozyme-Like Genes, Predominantly Expressed in the Male Reproductive System of Humans, Belonging to the C-Type Lysozyme/Alpha-Lactalbumin Family
Biol Reprod 2005 73: 1064-1071. [Abstract] [Full Text] [PDF]  

Summary: Four genes, three of which are novel, encoding lysozyme-like proteins and arising from a common progenitor gene, play a major role in human reproduction

Mechanisms of Hormone Action:

Daniel Baron, Remi Houlgatte, Alexis Fostier, and Yann Guiguen

Large-Scale Temporal Gene Expression Profiling During Gonadal Differentiation and Early Gametogenesis in Rainbow Trout
Biol Reprod 2005 73: 959-966. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Summary: Gene profiles during gonadal sex differentiation and early gametogenesis in trout indicate conservation of the sex differentiation cascade in vertebrates and reveal potential new molecular players in sex differentiation

Minireviews:

Attila Nagy and Andrew V. Schally

Targeting of Cytotoxic Luteinizing Hormone-Releasing Hormone Analogs to Breast, Ovarian, Endometrial, and Prostate Cancers
Biol Reprod 2005 73: 851-859. [Abstract] [Full Text] [PDF]  

Summary: The development of two chemotherapeutic agents designed to target LHRH receptors on breast, ovarian, prostate, and endometrial cancers is described

Carola Leuschner and William Hansel

Targeting Breast and Prostate Cancers Through Their Hormone Receptors
Biol Reprod 2005 73: 860-865. [Abstract] [Full Text] [PDF]  

Summary: Primary tumors and metastases from human breast and prostate cancer xenografts are selectively destroyed by lytic peptide-betaCG conjugates

Otabek Imamov, Gil-Jin Shim, Margaret Warner, and Jan-Åke Gustafsson

Estrogen Receptor beta in Health and Disease
Biol Reprod 2005 73: 866-871. [Abstract] [Full Text] [PDF]  

Summary: The roles of estrogen receptor alpha and estrogen receptor beta in human diseases, including leukemia and prostatic hyperplasia, are reviewed

Ovary:

Marta Tesone, Richard L. Stouffer, Sherri M. Borman, Jon D. Hennebold, and Theodore A. Molskness

Vascular Endothelial Growth Factor (VEGF) Production by the Monkey Corpus Luteum During the Menstrual Cycle: Isoform-Selective Messenger RNA Expression In Vivo and Hypoxia-Regulated Protein Secretion In Vitro
Biol Reprod 2005 73: 927-934. [Abstract] [Full Text] [PDF]  

Summary: Hypoxia, not LH, stimulates the primate corpus luteum to secrete VEGF, which is primarily the 165- and 121-amino acid isoforms

Phillip Kezele, Eric E. Nilsson, and Michael K. Skinner

Keratinocyte Growth Factor Acts as a Mesenchymal Factor That Promotes Ovarian Primordial to Primary Follicle Transition
Biol Reprod 2005 73: 967-973. [Abstract] [Full Text] [PDF]  

Summary: Precursor theca-granulosa cell interactions involving keratinocyte growth factor (KGF/FGF7) and kit ligand (KITL) promote primordial follicle development

Pregnancy:

Kou-ichi Jishage, Takanori Tachibe, Tsuneo Ito, Norihito Shibata, Shigeo Suzuki, Toshio Mori, Toshio Hani, Hiroyuki Arai, and Hiroshi Suzuki

Vitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself
Biol Reprod 2005 73: 983-987. [Abstract] [Full Text] [PDF]  

Summary: Alpha-tocopherol is indispensable for the proliferation and/or function of the placenta but not necessary for development of the embryo itself.

R. Ann Word, Charles P. Landrum, Brenda C. Timmons, Stephen G. Young, and Mala S. Mahendroo

Transgene Insertion on Mouse Chromosome 6 Impairs Function of the Uterine Cervix and Causes Failure of Parturition
Biol Reprod 2005 73: 1046-1056. [Abstract] [Full Text] [PDF]  

Summary: Transgene insertional mutation has led to the altered expression of a mouse gene required for normal cervical function at parturition

Reproductive Technology:

Pamela K. Kreeger, Nisha N. Fernandes, Teresa K. Woodruff, and Lonnie D. Shea

Regulation of Mouse Follicle Development by Follicle-Stimulating Hormone in a Three-Dimensional In Vitro Culture System Is Dependent on Follicle Stage and Dose
Biol Reprod 2005 73: 942-950. [Abstract] [Full Text] [PDF]  

Summary: Two-layered secondary follicles were FSH responsive, and multilayered secondary follicles were FSH dependent, when cultured in a three-dimensional alginate culture system; FSH dose regulated follicle growth, steroid secretion, and oocyte maturation

Special Papers:

William Hansel

Targeting Breast, Prostate, Ovarian, and Testicular Cancers Through Their Hormone Receptors
Biol Reprod 2005 73: 850. [Abstract] [Full Text] [PDF]  

Summary:

Testis:

Rüdiger W. Schulz, Sandra Menting, Jan Bogerd, Luiz R. França, Daniel A.R. Vilela, and Hugo P. Godinho

Sertoli Cell Proliferation in the Adult Testis—Evidence from Two Fish Species Belonging to Different Orders
Biol Reprod 2005 73: 891-898. [Abstract] [Full Text] [PDF]  

Summary: Sertoli cells proliferate in adult fish, particularly in spermatogenic cysts in late spermatogonia

Carolina Mondillo, Zoraida Patrignani, Cecilia Reche, Elena Rivera, and Omar Pignataro

Dual Role of Histamine in Modulation of Leydig Cell Steroidogenesis via HRH1 and HRH2 Receptor Subtypes
Biol Reprod 2005 73: 899-907. [Abstract] [Full Text] [PDF]  

Summary: Histamine modulates Leydig cell steroidogenesis via HRH1 and HRH2 receptor subtypes, pointing to a new physiological site of action for histamine

Anyanee Buageaw, Meena Sukhwani, Ahmi Ben-Yehudah, Jens Ehmcke, Vanesa Y. Rawe, Chumpol Pholpramool, Kyle E. Orwig, and Stefan Schlatt

GDNF Family Receptor alpha1 Phenotype of Spermatogonial Stem Cells in Immature Mouse Testes
Biol Reprod 2005 73: 1011-1016. [Abstract] [Full Text] [PDF]  

Summary: Spermatogonial stem cells can be enriched using magnetic activated cell sorting with GFRA1 antibodies, revealing a distinct GFRA1-positive subpopulation in the mouse pup testis that coexpresses the pluripotency marker POU5F1

Xiao Huang, Yiqing Guo, Yi Shui, Shang Gao, Hongshi Yu, Hanhua Cheng, and Rongjia Zhou

Multiple Alternative Splicing and Differential Expression of dmrt1 During Gonad Transformation of the Rice Field Eel
Biol Reprod 2005 73: 1017-1024. [Abstract] [Full Text] [PDF]  

Summary: Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation of rice field eel suggest that regulation at the level of splicing of Dmrt1 transcripts governs sex differentiation

Kathryn K. Stein, Jowell C. Go, Paul Primakoff, and Diana G. Myles

Defects in Secretory Pathway Trafficking During Sperm Development in Adam2 Knockout Mice
Biol Reprod 2005 73: 1032-1038. [Abstract] [Full Text] [PDF]  

Summary: Cyritestin loss in Adam2-knockout mice may result, at least in part, from a disruption in protein trafficking

Toxicology:

Daesuk Chung and Rita Loch Caruso

2,2'-Dichlorobiphenyl Decreases Amplitude and Synchronization of Uterine Contractions Through MAPK1-Mediated Phosphorylation of GJA1 (Connexin43) and Inhibition of Myometrial Gap Junctions
Biol Reprod 2005 73: 974-982. [Abstract] [Full Text] [PDF]  

Summary: 2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK-mediated phosphorylation of Connexin43 and inhibition of myometrial gap junctions

Matthew R. Milnes, Dieldrich S. Bermudez, Teresa A. Bryan, Mark P. Gunderson, and Louis J. Guillette, Jr.

Altered Neonatal Development and Endocrine Function in Alligator mississippiensis Associated with a Contaminated Environment
Biol Reprod 2005 73: 1004-1010. [Abstract] [Full Text] [PDF]  

Summary: Key developmental indices between two alligator populations of varying reproductive success are compared to lay the groundwork for environmental impact studies

Additions and Corrections:

Biol Reprod 2005 73: 1072. [Full Text] [PDF]  

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