Highlights:

Mitch Eddy, John Eppig, Mary Ann Handel, Sue Moenter, and Doug Stocco

Highlights
Biol Reprod 2005 73: 1077. [Full Text] [PDF]  

Embryo:

Kazuhiro Kawamura, Jun Fukuda, Yasushi Shimizu, Hideya Kodama, and Toshinobu Tanaka

Survivin Contributes to the Anti-Apoptotic Activities of Transforming Growth Factor alpha in Mouse Blastocysts Through Phosphatidylinositol 3'-Kinase Pathway
Biol Reprod 2005 73: 1094-1101. [Abstract] [Full Text] [PDF]  

Summary: TGFA inhibits apoptosis in mouse blastocysts through upregulation of survivin expression via PI3K pathway

Melissa L.M. Khoo, Leon R. McQuade, Murray S.R. Smith, Justin G. Lees, Kuldip S. Sidhu, and Bernard E. Tuch

Growth and Differentiation of Embryoid Bodies Derived from Human Embryonic Stem Cells: Effect of Glucose and Basic Fibroblast Growth Factor
Biol Reprod 2005 73: 1147-1156. [Abstract] [Full Text] [PDF]  

Summary: Prolonged culture of human embryoid bodies leads to the development of tissues of a mesodermal lineage, mainly hyaline cartilage

Myeong Seop Lee, Sung Keun Kang, Byeong Chun Lee, and Woo Suk Hwang

The Beneficial Effects of Insulin and Metformin on In Vitro Developmental Potential of Porcine Oocytes and Embryos
Biol Reprod 2005 73: 1264-1268. [Abstract] [Full Text] [PDF]  

Summary: Insulin increased the developmental potential of porcine oocytes and embryos by increasing oocyte GSH content and tyrosine kinase act activity and metformin enhanced the action of insulin on embryo development in vitro

Female Reproductive Tract:

Carmencita Rojas-Cartagena, Caroline B. Appleyard, Olga I. Santiago, and Idhaliz Flores

Experimental Intestinal Endometriosis Is Characterized by Increased Levels of Soluble TNFRSF1B and Downregulation of Tnfrsf1a and Tnfrsf1b Gene Expression
Biol Reprod 2005 73: 1211-1218. [Abstract] [Full Text] [PDF]  

Summary: Decreased gene expression of Tnfrsf1a and Tnfrsf1b, and increased shedding of TNFRSF1B, in an animal model of intestinal endometriosis provide further evidence for a key role of TNF-receptor modulation in development of this disease

Aki Shimizu, Tetsuo Maruyama, Kayoko Tamaki, Hiroshi Uchida, Hironori Asada, and Yasunori Yoshimura

Impairment of Decidualization in SRC-Deficient Mice
Biol Reprod 2005 73: 1219-1227. [Abstract] [Full Text] [PDF]  

Summary: SRC is indispensable for maximal decidualization in vivo and in vitro in mice

Jeffrey Pudney, Alison J. Quayle, and Deborah J. Anderson

Immunological Microenvironments in the Human Vagina and Cervix: Mediators of Cellular Immunity Are Concentrated in the Cervical Transformation Zone
Biol Reprod 2005 73: 1253-1263. [Abstract] [Full Text] [PDF]  

Summary: Regional variations in location and abundance of subpopulations of T-lymphocytes and antigen-presenting cells occur in the lower female genital tract and are unaffected by the menstrual cycle but are dramatically affected by inflammation

Gamete Biology:

Ashley I. Yudin, Suzanne E. Generao, Theodore L. Tollner, Catherine A. Treece, James W. Overstreet, and Gary N. Cherr

Beta-Defensin 126 on the Cell Surface Protects Sperm from Immunorecognition and Binding of Anti-Sperm Antibodies
Biol Reprod 2005 73: 1243-1252. [Abstract] [Full Text] [PDF]  

Summary: Sperm coating protein beta-defensin 126, previously known as ESP13.2, may protect sperm, which are potentially highly antigenic, from immunorecognition in the female reproduction tract during fertilization

Masashi Kinukawa, Junko Ohmuro, Shoji A. Baba, Sunao Murashige, Makoto Okuno, Masao Nagata, and Fugaku Aoki

Analysis of Flagellar Bending in Hamster Spermatozoa: Characterization of an Effective Stroke
Biol Reprod 2005 73: 1269-1274. [Abstract] [Full Text] [PDF] [Videos]  

Summary: The flagellar bending in hamster spermatozoa alternately produces effective and ineffective strokes for progressive movement

Immunology:

Abdorrahman S. Alghamdi and Douglas N. Foster

Seminal DNase Frees Spermatozoa Entangled in Neutrophil Extracellular Traps
Biol Reprod 2005 73: 1174-1181. [Abstract] [Full Text] [PDF] [Videos]  

Summary: Sperm that encounter neutrophils display less motility and fertility because of entrapment by the extrusion of neutrophil DNA, which is reduced by the enzymatic activity of seminal DNase

Male Reproductive Tract:

Xiaoping Ma, Andrea Reyna, Shailaja K. Mani, Martin M. Matzuk, and T. Rajendra Kumar

Impaired Male Sexual Behavior in Activin Receptor Type II Knockout Mice
Biol Reprod 2005 73: 1182-1190. [Abstract] [Full Text] [PDF]  

Summary: Male reproductive behavioral defects in activin receptor mutants are correlated to NOS activity in the preoptic area

Dolores Vernet, Gaby Nolazco, Liliana Cantini, Thomas R. Magee, Ansha Qian, Jacob Rajfer, and Nestor F. Gonzalez-Cadavid

Evidence That Osteogenic Progenitor Cells in the Human Tunica Albuginea May Originate from Stem Cells: Implications for Peyronie Disease
Biol Reprod 2005 73: 1199-1210. [Abstract] [Full Text] [PDF]  

Summary: Osteogenic commitment of stem cells in the human penile tunica albuginea may be responsible for plaque calcification and ossification in Peyronie disease

Mechanisms of Hormone Action:

Darryl L. Hadsell, Daniel T. Torres, Nicole A. Lawrence, Jessy George, Albert F. Parlow, Adrian V. Lee, and Marta L. Fiorotto

Overexpression of Des(1–3) Insulin-Like Growth Factor 1 in the Mammary Glands of Transgenic Mice Delays the Loss of Milk Production with Prolonged Lactation
Biol Reprod 2005 73: 1116-1125. [Abstract] [Full Text] [PDF]  

Summary: Overexpressed des(1-3)IGF1 enhanced milk synthesis and mammary development during prolonged lactation through localized and direct activation of the mammary gland IGF1 receptor and through systemic effects on prolactin secretion and nutrient balance

Minireviews:

Herbert Schuel and Lani J. Burkman

A Tale of Two Cells: Endocannabinoid-Signaling Regulates Functions of Neurons and Sperm
Biol Reprod 2005 73: 1078-1086. [Abstract] [Full Text] [PDF]  

Summary: Endocannabinoid signaling regulates functions of sea urchin and human sperm required for fertilization by processes analogous to those that operate in neurons

Neuroendocrinology:

Nancy L. Wayne, Kenrick Kuwahara, Katsumi Aida, Yoshitaka Nagahama, and Kataaki Okubo

Whole-Cell Electrophysiology of Gonadotropin-Releasing Hormone Neurons that Express Green Fluorescent Protein in the Terminal Nerve of Transgenic Medaka (Oryzias latipes)
Biol Reprod 2005 73: 1228-1234. [Abstract] [Full Text] [PDF]  

Summary: Whole-cell, current-clamp recordings from excised, intact brain reveal that GnRH neurons expressing GFP in the terminal nerve of transgenic medaka show a beating pattern of spontaneous action potential firing

Ovary:

Alice Pierre, Claudine Pisselet, Joelle Dupont, Martine Bontoux, and Philippe Monget

Bone Morphogenetic Protein 5 Expression in the Rat Ovary: Biological Effects on Granulosa Cell Proliferation and Steroidogenesis
Biol Reprod 2005 73: 1102-1108. [Abstract] [Full Text] [PDF]  

Summary: BMP5 is expressed by rat granulosa cells and exerts specific biological effects

James A. MacLean, II, Manjeet K. Rao, Kari M.H. Doyle, JoAnne S. Richards, and Miles F. Wilkinson

Regulation of the Rhox5 Homeobox Gene in Primary Granulosa Cells: Preovulatory Expression and Dependence on SP1/SP3 and GABP
Biol Reprod 2005 73: 1126-1134. [Abstract] [Full Text] [PDF]  

Summary: The discovery that Rhox5 expression in granulosa cells is regulated by MAPK, ETS, and SP1 family members provides an opportunity to understand how these regulatory pathways and factors collaborate to regulate gene expression during ovulation

Minnie Hsieh, Derek Boerboom, Masayuki Shimada, Yuet Lo, Albert F. Parlow, Ulrich F.O. Luhmann, Wolfgang Berger, and JoAnne S. Richards

Mice Null for Frizzled4 (Fzd4^–/–) Are Infertile and Exhibit Impaired Corpora Lutea Formation and Function
Biol Reprod 2005 73: 1135-1146. [Abstract] [Full Text] [PDF]  

Summary: Mice null for Fzd4 (Fzd4-/-) are infertile with defective corpora luteum formation

Pregnancy:

Catrin S. Rutland, Mallinath Mukhopadhyay, Suzanne Underwood, Norma Clyde, Terry M. Mayhew, and Christopher A. Mitchell

Induction of Intrauterine Growth Restriction by Reducing Placental Vascular Growth with the Angioinhibin TNP-470
Biol Reprod 2005 73: 1164-1173. [Abstract] [Full Text] [PDF]  

Summary: TNP-470, an antiangiogenic agent, caused intrauterine growth restriction and aberrant blood vessel formation when administered during the latter half of pregnancy

C.S. Thota, L.C. Reed, and C. Yallampalli

Effects of Parathyroid Hormone Like Hormone (PTHLH) Antagonist, PTHLH_7–34, on Fetoplacental Development and Growth During Midgestation in Rats
Biol Reprod 2005 73: 1191-1198. [Abstract] [Full Text] [PDF]  

Summary: PTHLH antagonist infusion leads to decreased placental development and fetal growth during midgestation through increased placental apoptosis in rats

Edward D. Johnstone, Colin P. Sibley, Bonnie Lowen, and Larry J. Guilbert

Epidermal Growth Factor Stimulation of Trophoblast Differentiation Requires MAPK11/14 (p38 MAP Kinase) Activation
Biol Reprod 2005 73: 1282-1288. [Abstract] [Full Text] [PDF]  

Summary: EGF-stimulated trophoblast differentiation requires MAPK1 activity

Olivier W.H. van der Heijden, Yvonne P.G. Essers, Marc E.A. Spaanderman, Jo G.R. De Mey, Guillaume J.J.M. van Eys, and Louis L.H. Peeters

Uterine Artery Remodeling in Pseudopregnancy Is Comparable to That in Early Pregnancy
Biol Reprod 2005 73: 1289-1293. [Abstract] [Full Text] [PDF]  

Summary: Uterine artery remodeling in pregnancy is initiated without appreciable role of the conceptus

Frankie J. White, Jason W. Ross, Margaret M. Joyce, Rodney D. Geisert, Robert C. Burghardt, and Greg A. Johnson

Steroid Regulation of Cell Specific Secreted Phosphoprotein 1 (Osteopontin) Expression in the Pregnant Porcine Uterus
Biol Reprod 2005 73: 1294-1301. [Abstract] [Full Text] [PDF]  

Summary: In pregnant pigs, SPP1 mRNA is induced by conceptus estrogen in uterine lumenal epithelium and by CL/placental progesterone in glandular epithelium

Reproductive Technology:

M.P. Green, L.D. Spate, J.A. Bixby, A.D. Ealy, and R.M. Roberts

A Comparison of the Anti-Luteolytic Activities of Recombinant Ovine Interferon-Alpha and -Tau in Sheep
Biol Reprod 2005 73: 1087-1093. [Abstract] [Full Text] [PDF]  

Summary: Equivalent antiviral units of ovIFNA and ovIFNT are equipotent in extending estrous cycle length in sheep

Ryota Suganuma, Pawel Pelczar, Jean François Spetz, Barbara Hohn, Ryuzo Yanagimachi, and Stefan Moisyadi

Tn5 Transposase-Mediated Mouse Transgenesis
Biol Reprod 2005 73: 1157-1163. [Abstract] [Full Text] [PDF]  

Summary: A novel method of active ICSI transgenesis using a transposase enzyme as the mediator of transgene insertion enables more effective transgenesis with fewer oocytes used

Carol Curchoe, Shouquan Zhang, Yanfang Bin, Xiquan Zhang, Lan Yang, Dingyuan Feng, Michael O'Neill, and X. Cindy Tian

Promoter-Specific Expression of the Imprinted IGF2 Gene in Cattle (Bos taurus)
Biol Reprod 2005 73: 1275-1281. [Abstract] [Full Text] [PDF]  

Summary: Age-, tissue-, promoter-, allele-specific expression of IGF2 and the promoter-specific loss of imprinting are of important reference value to cattle produced from embryo biotechnologies

Takashi Kohda, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Mie Naruse, Tomoko Kaneko-Ishino, Atsuo Ogura, and Fumitoshi Ishino

Variation in Gene Expression and Aberrantly Regulated Chromosome Regions in Cloned Mice
Biol Reprod 2005 73: 1302-1311. [Abstract] [Full Text] [PDF]  

Summary: Genome-wide gene expression analysis clearly demonstrates that the somatic cloning technique produces epigenetically divergent individuals despite their normal appearance and genetic identity

Testis:

David R. Simorangkir, Gary R. Marshall, Jens Ehmcke, Stefan Schlatt, and Tony M. Plant

Prepubertal Expansion of Dark and Pale Type A Spermatogonia in the Rhesus Monkey (Macaca mulatta) Results from Proliferation During Infantile and Juvenile Development in a Relatively Gonadotropin Independent Manner
Biol Reprod 2005 73: 1109-1115. [Abstract] [Full Text] [PDF]  

Summary: S-phase labeling with BrdU indicates that dark and pale type A spermatogonia in the rhesus monkey proliferate by mitosis during prepubertal development in a relatively gonadotropin independent manner

Jing-Ling Jin, Alan M. O'Doherty, Shouhua Wang, Huili Zheng, Kenton M. Sanders, and Wei Yan

Catsper3 and Catsper4 Encode Two Cation Channel-Like Proteins Exclusively Expressed in the Testis
Biol Reprod 2005 73: 1235-1242. [Abstract] [Full Text] [PDF]  

Summary: CATSPER3 and CATSPER4 are two novel channel-like proteins specifically expressed in the acrosome and spermatozoa

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