HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

COVER: From "The First Mitosis of the Mouse Embryo Is Prolonged by Transitional Metaphase Arrest" by Marta Sikora-Polaczek, Anna Hupalowska, Zbigniew Polanski, Jacek Z. Kubiak, and Maria A. Ciemerych. Biol Reprod 2006; 74:734-743. Published online ahead of print 28 December 2005; DOI 10.1095/biolreprod.105.047092. Confocal image of the mouse oocyte at the stage of the second meiotic metaphase with the spindle (red), chromosomes (blue) and MAD2L1 (green) labeled. Punctuate staining shows the presence of the spindle assembly checkpoint protein MAD2L1 attached to kinetochores. MAD2L1, however, is then gradually lost from the kinetochores. Precocious loss of MAD2L1 is also observed during prolonged metaphase in one-cell embryos suggesting similarity in mechanism responsible for the metaphase II arrest in oocytes and a transitory metaphase arrest during the mitosis of one-cell embryo. Cover design and layout: Jane Tenenbaum, Tenenbaum Design, Madison, Wisconsin. Biology of Reproduction is printed with soy-based inks on acid-free paper by Allen Press, Inc., Lawrence, Kansas. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage or retrieval system, without permission in writing from the Society for the Study of Reproduction, Inc. All rights reserved. POSTMASTER: Send address changes to Biology of Reproduction, 1619 Monroe Street, Madison, WI.