Highlights:

Highlights
Biol Reprod 2007 76: 737. [Full Text] [PDF]  

Embryo:

Jason R. Herrick, Jennifer B. Bond, Genevieve M. Magarey, Helen L. Bateman, Rebecca L. Krisher, Susan A. Dunford, and William F. Swanson

Toward a Feline-Optimized Culture Medium: Impact of Ions, Carbohydrates, Essential Amino Acids, Vitamins, and Serum on Development and Metabolism of In Vitro Fertilization-Derived Feline Embryos Relative to Embryos Grown In Vivo
Biol Reprod 2007 76: 858-870. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Summary: Approximately 70% of IVF-derived feline embryos develop into blastocysts with similar developmental kinetics and metabolic activity as in vivo embryos when cultured in an optimized medium based on the physiological needs of the feline embryo

Hiroshi Nagashima, Katsumi Hiruma, Hitoshi Saito, Ryo Tomii, Satoshi Ueno, Naoki Nakayama, Hitomi Matsunari, and Mayuko Kurome

Production of Live Piglets Following Cryopreservation of Embryos Derived from In Vitro-Matured Oocytes
Biol Reprod 2007 76: 900-905. [Abstract] [Full Text] [PDF]  

Summary: Live pigs can be produced following vitrification at early cleavage stage of embryos derived from oocytes matured and fertilized in vitro

Mei-Rong Du, Lin Dong, Wen-Hui Zhou, Feng-Ting Yan, and Da-Jin Li

Cyclosporin A Improves Pregnancy Outcome by Promoting Functions of Trophoblasts and Inducing Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings in the Mouse
Biol Reprod 2007 76: 906-914. [Abstract] [Full Text] [PDF]  

Summary: Cyclosporin A, an immunosuppressant, can regulate materno-fetal relationships and be useful in treatment of spontaneous pregnancy wastage and other pregnancy complications

Female Reproductive Tract:

Ching-wen Cheng, Holli Bielby, Di Licence, Stephen K. Smith, Cristin G. Print, and D. Stephen Charnock-Jones

Quantitative Cellular and Molecular Analysis of the Effect of Progesterone Withdrawal in a Murine Model of Decidualization
Biol Reprod 2007 76: 871-883. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Summary: Immune cells are recruited into decidualizing and menstruating endometrium, and immune-related genes are regulated in the uterus throughout menstruation

Gamete Biology:

Rebecca A. Dragovic, Lesley J. Ritter, Samantha J. Schulz, Fred Amato, Jeremy G. Thompson, David T. Armstrong, and Robert B. Gilchrist

Oocyte-Secreted Factor Activation of SMAD 2/3 Signaling Enables Initiation of Mouse Cumulus Cell Expansion
Biol Reprod 2007 76: 848-857. [Abstract] [Full Text] [PDF]  

Summary: Initiation of mouse cumulus cell expansion requires activation of the cumulus cell SMAD 2/3 signaling pathway by oocyte-secreted factors

Immunology:

Sarah A. Robertson, Alison S. Care, and Rebecca J. Skinner

Interleukin 10 Regulates Inflammatory Cytokine Synthesis to Protect Against Lipopolysaccharide-Induced Abortion and Fetal Growth Restriction in Mice
Biol Reprod 2007 76: 738-748. [Abstract] [Full Text] [PDF]  

Summary: The anti-inflammatory cytokine interleukin 10 (IL10) acts in pregnancy to prevent abortion and fetal growth restriction induced by proinflammatory cytokines in the implantation site.

Male Reproductive Tract:

Julie Dufresne and Daniel G. Cyr

Activation of an SP Binding Site Is Crucial for the Expression of Claudin 1 in Rat Epididymal Principal Cells
Biol Reprod 2007 76: 825-832. [Abstract] [Full Text] [PDF]  

Summary: The expression of Claudin 1 in the rat epididymis is regulated by SP1 and SP3 transcription factors that interact with one of two SP binding sites on the 5' flanking region of the gene.

Roumen Parapanov, Sébastien Nusslé, and Peter Vogel

Cycle Length of Spermatogenesis in Shrews (Mammalia: Soricidae) with High and Low Metabolic Rates and Different Mating Systems
Biol Reprod 2007 76: 833-840. [Abstract] [Full Text] [PDF]  

Summary: Shrews with high and low metabolic rates and different mating systems might represent a model to perform comparative studies related to the duration of spermatogenesis

M.G. Ferrini, I. Kovanecz, S. Sanchez, D. Vernet, H.H. Davila, J. Rajfer, and N.F. Gonzalez-Cadavid

Long-Term Continuous Treatment with Sildenafil Ameliorates Aging-Related Erectile Dysfunction and the Underlying Corporal Fibrosis in the Rat
Biol Reprod 2007 76: 915-923. [Abstract] [Full Text] [PDF]  

Summary: Long-term treatment with PDE5A inhibitors corrects CVOD and partially reverses the aging-related fibrosis and loss of corporal cavernosa smooth muscle in the aged rat

Mechanisms of Hormone Action:

Ori Eyal, Jean-Baptiste Jomain, Cherie Kessler, Vincent Goffin, and Stuart Handwerger

Autocrine Prolactin Inhibits Human Uterine Decidualization: A Novel Role for Prolactin
Biol Reprod 2007 76: 777-783. [Abstract] [Full Text] [PDF]  

Summary: hPRL acts via an autocrine mechanism to regulate negatively the extent of differentiation (decidualization) of human uterine cells.

Guénaëlle Levallet, Jérôme Levallet, Hélène Bouraïma-Lelong, and Pierre-Jacques Bonnamy

Expression of the cAMP-Phosphodiesterase PDE4D Isoforms and Age-Related Changes in Follicle-Stimulating Hormone-Stimulated PDE4 Activities in Immature Rat Sertoli Cells
Biol Reprod 2007 76: 794-803. [Abstract] [Full Text] [PDF]  

Summary: Age-related changes in FSH-stimulated PDE4 activities occur in rat Sertoli cells during the early postnatal period.

Ovary:

Tatiana Kisliouk, Aharon Friedman, Eyal Klipper, Qun-Yong Zhou, Dieter Schams, Nadia Alfaidy, and Rina Meidan

Expression Pattern of Prokineticin 1 and Its Receptors in Bovine Ovaries During the Estrous Cycle: Involvement in Corpus Luteum Regression and Follicular Atresia
Biol Reprod 2007 76: 749-758. [Abstract] [Full Text] [PDF]  

Summary: PROK1 plays a role in follicular atresia and CL regression by enhancing the recruitment and activation of leukocytes.

Pregnancy:

Marie-Josèphe Leroy, Emmanuelle Dallot, Isabelle Czerkiewicz, Thomas Schmitz, and Michelle Breuiller-Fouché

Inflammation of Choriodecidua Induces Tumor Necrosis Factor Alpha-Mediated Apoptosis of Human Myometrial Cells
Biol Reprod 2007 76: 769-776. [Abstract] [Full Text] [PDF]  

Summary: TNF secreted by choriodecidua during inflammation is an important component of a paracrine system for inducing myometrial cell apoptosis

Quinton A. Winger, Jillian Guttormsen, Heather Gavin, and Frances Bhushan

Heat Shock Protein 1 and the Mitogen-Activated Protein Kinase 14 Pathway Are Important for Mouse Trophoblast Stem Cell Differentiation
Biol Reprod 2007 76: 884-891. [Abstract] [Full Text] [PDF]  

Summary: HSPB1 and MAPKAPK2 are identified as proteins with increased phosphorylation during TS cell differentiation and the inhibition of MAPK14 results in decreased cell viability supporting a role for the MAPK14 pathway during TS cell differentiation.

Yuan-Lin Dong, Deepti M. Reddy, Kortney E. Green, Madhu S. Chauhan, Hui-Qun Wang, Manubai Nagamani, Gary D.V. Hankins, and Chandra Yallampalli

Calcitonin Gene-Related Peptide (CALCA) Is a Proangiogenic Growth Factor in the Human Placental Development
Biol Reprod 2007 76: 892-899. [Abstract] [Full Text] [PDF]  

Summary: CALCA induces angiogenesis in vitro by stimulating endothelial cell proliferation, migration, and capillary-like tube formation.

Testis:

Wendy R. Winnall, Ugur Ali, Moira K. O'Bryan, Jon J. Hirst, Penelope A.F. Whiley, Julie A. Muir, and Mark P. Hedger

Constitutive Expression of Prostaglandin-Endoperoxide Synthase 2 by Somatic and Spermatogenic Cells Is Responsible for Prostaglandin E₂ Production in the Adult Rat Testis
Biol Reprod 2007 76: 759-768. [Abstract] [Full Text] [PDF]  

Summary: In the adult rat testis, prostaglandin production is due to constitutive expression and activity of prostaglandin-endoperoxide synthase 2 in somatic and spermatogenic cells; inflammation induces marginal effects on enzyme expression or prostaglandin levels in the adult rat testis

Santhi Sridharan, Liz Simon, Daryl D. Meling, Daniel G. Cyr, David E. Gutstein, Glenn I. Fishman, Florian Guillou, and Paul S. Cooke

Proliferation of Adult Sertoli Cells Following Conditional Knockout of the Gap Junctional Protein GJA1 (Connexin 43) in Mice
Biol Reprod 2007 76: 804-812. [Abstract] [Full Text] [PDF]  

Summary: Sertoli cell-specific connexin 43 knockout mice possess proliferating Sertoli cells even in adulthood, suggesting that connexin 43 plays a critical role in Sertoli cell maturation

Martin Charron, Jing-Yi Chern, and William W. Wright

The Cathepsin L First Intron Stimulates Gene Expression in Rat Sertoli Cells
Biol Reprod 2007 76: 813-824. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Summary: The splicing of the first intron of the rat cathepsin L gene stimulates reporter gene activity by ~5-fold in primary Sertoli cell cultures and in the TM4 Sertoli cell line by increasing the amounts of total RNA and transcript polyadenylation

Kevin T. Ebata, Xiangfan Zhang, and Makoto C. Nagano

Male Germ Line Stem Cells Have an Altered Potential to Proliferate and Differentiate During Postnatal Development in Mice
Biol Reprod 2007 76: 841-847. [Abstract] [Full Text] [PDF]  

Summary: Spermatogonial stem cells derived from immature mouse testes exhibit a different proliferation pattern after transplantation, compared to those from adult intact testes

Toxicology:

Ursula Eichenlaub-Ritter, Ulrike Winterscheidt, Edgar Vogt, Ying Shen, Hans-Rudolf Tinneberg, and Ralph Sorensen

2-Methoxyestradiol Induces Spindle Aberrations, Chromosome Congression Failure, and Nondisjunction in Mouse Oocytes
Biol Reprod 2007 76: 784-793. [Abstract] [Full Text] [PDF]  

Summary: 2-Methoxyestradiol, a metabolite of 17β-estradiol, dose-dependently induces spindle aberrations, chromosome congression failure, and the spindle checkpoint; aneuploidy is dramatically increased in oocytes that escape meiotic arrest.

Additions and Corrections:

Mitch Eddy

Biol Reprod 2007 76: 924. [Full Text] [PDF]  

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