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COVER: From "2-Methoxyestradiol Induces Spindle Aberrations, Chromosome Congression Failure, and Nondisjunction in Mouse Oocytes" by Ursula Eichenlaub-Ritter, Ulrike Winterscheid, Edgar Vogt, Ying Shen, Hans-Rudolf Tinneberg, and Ralph Sorensen. Biol Reprod 2007; 76:784-793. Published online ahead of print 17 January 2007, DOI 10.1095/biolreprod.106.055111. Evidence for potential risks of meiotic errors in mammalian oocytes by exposures to environmental pollutants: High 2-methoxyestradiol, an environmentally inducible natural metabolite of estradiol, causes spindle aberrations (green), interferes with alignment of microtubule organizing centres at the spindle poles (marked by pericentrin antibody, orange), and induces high rates of aneuploidy in in vitro maturing mouse oocytes. Cover design and layout: Jane Tenenbaum, Tenenbaum Design, Cambridge, Massachusetts. Biology of Reproduction is printed with soy-based inks on acid-free paper by Allen Press, Inc., Lawrence, Kansas.