Highlights:

Highlights
Biol Reprod 2008 78: 567. [Full Text] [PDF]  

Embryo:

Yuko Jincho, Yusuke Sotomaru, Manabu Kawahara, Yukiko Ono, Hidehiko Ogawa, Yayoi Obata, and Tomohiro Kono

Identification of Genes Aberrantly Expressed in Mouse Embryonic Stem Cell-Cloned Blastocysts
Biol Reprod 2008 78: 568-576. [Abstract] [Full Text] [PDF]  

Summary: Differential screening of subtraction libraries revealed 224 differentially expressed genes in embryonic stem cell-cloned blastocysts, performing a wide range of functions

Marie Pantaleon, Jeanie Scott, and Peter L. Kaye

Nutrient Sensing by the Early Mouse Embryo: Hexosamine Biosynthesis and Glucose Signaling During Preimplantation Development
Biol Reprod 2008 78: 595-600. [Abstract] [Full Text] [PDF]  

Summary: Glucose is a regulator of gene expression during early (cleavage stage) development and the hexosamine biosynthetic pathway is a key pathway by which glucose acts to facilitate blastocyst formation in the mouse

Gamete Biology:

Agnieszka Wojtczak and Maria Kwiatkowska

Immunocytochemical and Ultrastructural Analyses of the Function of the Ubiquitin-Proteasome System During Spermiogenesis with the Use of the Inhibitors of Proteasome Proteolytic Activity in the Alga, Chara vulgaris
Biol Reprod 2008 78: 577-585. [Abstract] [Full Text] [PDF]  

Summary: Ubiquitin-proteasome system is indispensable for the proper course of early spermiogenesis and for nuclear protein replacement and changes of the nucleus structure at later stages as well as for removal of superfluous histones.

Baisong Lu, Christophe Poirier, Tamas Gaspar, Christian Gratzke, Wilbur Harrison, David Busija, Martin M. Matzuk, Karl-Erik Andersson, Paul A. Overbeek, and Colin E. Bishop

A Mutation in the Inner Mitochondrial Membrane Peptidase 2-Like Gene (Immp2l) Affects Mitochondrial Function and Impairs Fertility in Mice
Biol Reprod 2008 78: 601-610. [Abstract] [Full Text] [PDF]  

Summary: A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects the function of mitochondria, which generate excessive superoxide; the phenotype is impaired fertility due to erectile dysfunction and defects in folliculogenesis

C. Lalancette, C. Thibault, I. Bachand, N. Caron, and N. Bissonnette

Transcriptome Analysis of Bull Semen with Extreme Nonreturn Rate: Use of Suppression-Subtractive Hybridization to Identify Functional Markers for Fertility
Biol Reprod 2008 78: 618-635. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Summary: Differential transcript profiling of spermatozoa from fertile bulls that presented extreme field fertility allowed the identification of novel genes with intriguing potential function, such as desiccation tolerance or developmental control of genes

Andrea DiLuigi, Vanessa N. Weitzman, Margaret C. Pace, Linda J. Siano, Donald Maier, and Lisa M. Mehlmann

Meiotic Arrest in Human Oocytes Is Maintained by a G_s Signaling Pathway
Biol Reprod 2008 78: 667-672. [Abstract] [Full Text] [PDF]  

Summary: The Gs signaling pathway is required for the maintenance of meiotic arrest in immature human oocytes

Lu Sun, Rawad Hodeify, Shirley Haun, Amanda Charlesworth, Angus M. MacNicol, Subramaniam Ponnappan, Usha Ponnappan, Claude Prigent, and Khaled Machaca

Ca²⁺ Homeostasis Regulates Xenopus Oocyte Maturation
Biol Reprod 2008 78: 726-735. [Abstract] [Full Text] [PDF]  

Summary: Ca2+ deprivation inhibits meiosis I progression and aurora kinase A protein accumulation

Immunology:

Jenifer Monks, Christine Smith-Steinhart, Ellen R. Kruk, Valerie A. Fadok, and Peter M. Henson

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland
Biol Reprod 2008 78: 586-594. [Abstract] [Full Text] [PDF]  

Summary: Apoptotic cell clearance, previously thought to be mediated by cells of the immune system, is found to be mediated by alveolar epithelial cells during post-weaning involution of the mouse mammary gland

Kalidou Ndiaye, Daniel H. Poole, and Joy L. Pate

Expression and Regulation of Functional Oxytocin Receptors in Bovine T Lymphocytes
Biol Reprod 2008 78: 786-793. [Abstract] [Full Text] [PDF]  

Summary: Bovine lymphocytes express oxytocin receptors that elicit calcium mobilization and are steroid-regulated, as well as oxytocin-neurophysin, the precursor of secreted oxytocin

Neuroendocrinology:

A. Veiga-Lopez, W. Ye, D.J. Phillips, C. Herkimer, P.G. Knight, and V. Padmanabhan

Developmental Programming: Deficits in Reproductive Hormone Dynamics and Ovulatory Outcomes in Prenatal, Testosterone-Treated Sheep
Biol Reprod 2008 78: 636-647. [Abstract] [Full Text] [PDF]  

Summary: Prenatal testosterone treatment disrupts periovulatory hormonal dynamics and culminates in oligo- anovulation in adult females

Mohan Manikkam, Robert C. Thompson, Carol Herkimer, Kathleen B. Welch, Jonathan Flak, Fred J. Karsch, and Vasantha Padmanabhan

Developmental Programming: Impact of Prenatal Testosterone Excess on Pre- and Postnatal Gonadotropin Regulation in Sheep
Biol Reprod 2008 78: 648-660. [Abstract] [Full Text] [PDF]  

Summary: Prenatal testosterone excess amplifies GnRH-induced LH secretion by its androgenic action, causes developmental changes in expression of pituitary genes involved in regulating LH and FSH, and culminates in LH hypersecretion and acyclicity in adulthood

Mark E. Wilson and Becky Kinkead

Gene-Environment Interactions, Not Neonatal Growth Hormone Deficiency, Time Puberty in Female Rhesus Monkeys
Biol Reprod 2008 78: 736-743. [Abstract] [Full Text] [PDF]  

Summary: Social subordination during development significantly delays puberty in female rhesus monkeys, and this effect is exacerbated in females with a specific polymorphism in the gene that encodes the serotonin reuptake transporter

Ovary:

Ramón Sotomayor-Zárate, Mauricio Dorfman, Alfonso Paredes, and Hernán E. Lara

Neonatal Exposure to Estradiol Valerate Programs Ovarian Sympathetic Innervation and Follicular Development in the Adult Rat
Biol Reprod 2008 78: 673-680. [Abstract] [Full Text] [PDF]  

Summary: Neonatal exposure to estradiol produced an acute increase in the intraovarian levels of Ngfb and Ngfr mRNAs, permanently modified sympathetic activity, caused profound changes in follicular development, and originated polycystic ovary

Matthew D. Doerr, Madhusudan P. Goravanahally, Justin D. Rhinehart, E. Keith Inskeep, and Jorge A. Flores

Effects of Endothelin Receptor Type-A and Type-B Antagonists on Prostaglandin F_2alpha-Induced Luteolysis of the Sheep Corpus Luteum
Biol Reprod 2008 78: 688-696. [Abstract] [Full Text] [PDF]  

Summary: There are early EDN1-independent and later EDN1-dependent actions of PGF2{alpha} during PGF2{alpha}-induced luteolysis in sheep

Elsa De La Chesnaye, Bredford Kerr, Alfonso Paredes, Horacio Merchant-Larios, Juan Pablo Méndez, and Sergio R. Ojeda

Fbxw15/Fbxo12J Is an F-Box Protein-Encoding Gene Selectively Expressed in Oocytes of the Mouse Ovary
Biol Reprod 2008 78: 714-725. [Abstract] [Full Text] [PDF]  

Summary: A gene encoding an F-box protein was found to be specifically expressed in mouse oocytes in a developmentally regulated fashion

Pituitary:

Joseph P. Moore, ,Jr. and Stephen J. Winters

Weaning and the Developmental Changes in Follicle-Stimulating Hormone, Pituitary Adenylate Cyclase-Activating Polypeptide, and Inhibin B in the Male Rat
Biol Reprod 2008 78: 752-760. [Abstract] [Full Text] [PDF]  

Summary: Weaning and the subsequent acceleration in growth rate are associated with a predominant rise in FSH that is negatively correlated to decreases in circulating inhibin B and pituitary expression of follistatin and Adycap1

Pregnancy:

Hui Zhao, Ronald J. Wong, Timothy C. Doyle, Nihar Nayak, Hendrik J. Vreman, Christopher H. Contag, and David K. Stevenson

Regulation of Maternal and Fetal Hemodynamics by Heme Oxygenase in Mice
Biol Reprod 2008 78: 744-751. [Abstract] [Full Text] [PDF]  

Summary: Heme oxygenase and its metabolite, carbon monoxide, play important roles in regulating maternal vascular tone, placental perfusion, and fetal hemodynamic function

Reproductive Technology:

Mito Kanatsu-Shinohara, Tomomi Muneto, Jiyoung Lee, Manami Takenaka, Shinichiro Chuma, Norio Nakatsuji, Toshitaka Horiuchi, and Takashi Shinohara

Long-Term Culture of Male Germline Stem Cells From Hamster Testes
Biol Reprod 2008 78: 611-617. [Abstract] [Full Text] [PDF]  

Summary: A long-term culture system for hamster spermatogonial stem cells is developed

Camryn D. Allen, Michelle Burridge, Sarah Mulhall, Mandy L. Chafer, Vere N. Nicolson, Michael Pyne, Yeng Peng Zee, Sophia C. Jago, Geoff Lundie-Jenkins, William V. Holt, Frank N. Carrick, Jonathan D. Curlewis, Allan T. Lisle, and Stephen D. Johnston

Successful Artificial Insemination in the Koala (Phascolarctos cinereus) Using Extended and Extended-Chilled Semen Collected by Electroejaculation
Biol Reprod 2008 78: 661-666. [Abstract] [Full Text] [PDF]  

Summary: AI with extended and chill-stored semen produces koala pouch young

Raúl Fernández-Gonzalez, Pedro Nuno Moreira, Miriam Pérez-Crespo, Manuel Sánchez-Martín, Miguel Angel Ramirez, Eva Pericuesta, Ainhoa Bilbao, Pablo Bermejo-Alvarez, Juan de Dios Hourcade, Fernando Rodriguez de Fonseca, and Alfonso Gutiérrez-Adán

Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring
Biol Reprod 2008 78: 761-772. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Summary: ICSI with DNA-fragmented sperm produces a variety of deleterious phenotypes in mice

Testis:

Mito Kanatsu-Shinohara, Jiyoung Lee, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Shinya Toyokuni, Masahito Ikawa, Tomoyuki Nakamura, Atsuo Ogura, and Takashi Shinohara

Pluripotency of a Single Spermatogonial Stem Cell in Mice
Biol Reprod 2008 78: 681-687. [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Summary: A single spermatogonial stem cell can differentiate into multiple somatic cell types

Marina G. Yefimova, Amina Sow, Isabelle Fontaine, Vincent Guilleminot, Nadine Martinat, Pascale Crepieux, Sylvie Canepa, Marie-Christine Maurel, Sophie Fouchécourt, Eric Reiter, Omar Benzakour, and Florian Guillou

Dimeric Transferrin Inhibits Phagocytosis of Residual Bodies by Testicular Rat Sertoli Cells
Biol Reprod 2008 78: 697-704. [Abstract] [Full Text] [PDF]  

Summary: Addition of purified dimeric transferrin inhibits phagocytosis of residual bodies by Sertoli cells and rescues Tf siRNA-mediated knock-down of Sertoli cells

Saleela M. Ruwanpura, Robert I. McLachlan, Peter G. Stanton, and Sarah J. Meachem

Follicle-Stimulating Hormone Affects Spermatogonial Survival by Regulating the Intrinsic Apoptotic Pathway in Adult Rats
Biol Reprod 2008 78: 705-713. [Abstract] [Full Text] [PDF]  

Summary: FSH predominantly regulates spermatogonial survival, rather than proliferation, in adult rats by regulating the intrinsic apoptotic pathway

Yuen-Fan Chan, Wai-Sum O, and Fai Tang

Adrenomedullin in the Rat Testis. I: Its Production, Actions on Testosterone Secretion, Regulation by Human Chorionic Gonadotropin, and Its Interaction with Endothelin 1 in the Leydig Cell
Biol Reprod 2008 78: 773-779. [Abstract] [Full Text] [PDF]  

Summary: Adrenomedullin has an autocrine effect on Leydig cell steroidogenesis by interacting with endothelin 1 and gonadotropin

Yuen-Fan Chan, Fai Tang, and Wai-Sum O

Adrenomedullin in the Rat Testis. II: Its Production, Actions on Inhibin Secretion, Regulation by Follicle-Stimulating Hormone, and Its Interaction with Endothelin 1 in the Sertoli Cell
Biol Reprod 2008 78: 780-785. [Abstract] [Full Text] [PDF]  

Summary: Adrenomedullin and endothelin 1 were found to regulate each other in opposite directions in the Sertoli cells

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